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Quick Detail
Product name | 99% purity Dapoxetine hydrochloride |
CAS | 129938-20-1 |
Molecular Formula | C9H7ClN2O5 |
Molecular Weight | 258.62 |
Assay | 99%min |
Grade | Pharma Grade |
Packaging detail | 25kgs/Drum |
COA
Item | Requirement | Result |
Appearance | White or almost white crystalline powder | Almost White Powder |
Melting Point | 175°C-185°C | 181.2°C-182.8°C |
Optical Rotation | +128±3 (C=1, CH3OH) | 127.33 |
Loss on Drying | ≤1.0% | 0.20% |
Ignition Residue | ≤0.1% | 0.10% |
Purity | ≥98.5% | 99.47% |
Characteristics: | white powder, odorless, no bitter, used in tablet, capsule and so on Function: As a new and high-speed SSRi, is held with short of half-life. It is belonging to the selective 5-hydroxytryptamine reabsorption inhibitor(SSRI), with high effect in premature Ejaculation and ED. |
Feature: | It is absorbed by stomach, and can be effected after 30-60mins, lasts for several dasy, without side-effect, can't be detected, accompanying light headache, sick, but can disappear soon. |
Application
Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.
Description
Premature ejaculation (PE) is the most common male sexual dysfunction. hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), and adverse effect (AE) incidence associated with the use of (30 mg and 60 mg) versus placebo, and evaluate the differences in administering 60 mg versus 30 mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis.
Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that (in the 30 mg and 60 mg subgroup) resulted in significantly higher IELT, PGIC, and AE incidence relative to the placebo, with higher proportions observed for 60 mg versus 30 mg of administration. The most common AEs were mild and tolerable. We conclude that (particularly the 60 mg dosage) may be considered a safe and effective drug for patients with PE.
Dapoxetine hydrochloride is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression.
Sexual dysfunction, including premature ejaculation, is an extremely common condition worldwide. The cause of premature ejaculation has not been fully elucidated, but may include both psychological and physiological factors. Premature ejaculation refers to a short ejaculation time, which can affect the satisfaction of both partners during sexual intercourse.
To treat premature ejaculation, both psychological and physiological factors need to be managed. From a pharmacological point-of-view, to treat the physiological aspect of premature ejaculation, dapoxetine hydrochloride is one of the first oral drugs to be made available. Psychological treatment may be given concomitantly, as the condition is multifactorial.
Usage
Hydrochloride is an oral drug for the treatment of ED, used in the treatment of erectile dysfunction and premature ejaculation, erectile function impairment and premature ejaculation has very significant improvements. There are over 1500 documents to prove the caused by different causes impotence premature ejaculation, knew the success rate is above 80%, and show its reliable curative effect, through the use of more than 20 million people worldwide, proved its long-term stability, the safety of 25 to 60 minutes of work function to coincide with a time needed for foreplay, knew the time adjustment in the highest drug concentration time, help both husband and wife a satisfactory sex life.
Initially, hydrochloride is given as a 30 mg tablet one to three hours before sexual intercourse. The dose may be increased by the prescribing doctor to 60 mg, depending on response and tolerance. The tablet should be taken with water and may be taken with or without food, as absorption is not affected by food.
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